Electroacupuncture promotes nerve regeneration and functional recovery in rats with spinal cord contusion through the coordinate interaction of CD4 and BDNF

To explore the effect of electroacupuncture on spinal cord injury (SCI) involving immune-related factors and regeneration-related in rats. The model contusion was established by PCI 3000 instrument. Two types acupuncture points were selected for treatment rats tested once a week, fiber remodeling detected magnetic resonance imaging. Transcriptome sequencing performed scar samples. Using Python to write code, statistical analysis bioinformatics correlation between transcriptome data reconstruction results are carried out. Lastly, expression CD4 brain-derived neurotrophic factor (BDNF) verified quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Electroacupuncture exhibited positive recovery motor function after SCI. Bioinformatics found direct interaction BDNF. PCR that significantly reduced CD4, increased BDNF, simultaneously corresponding nerve regeneration with Our showed intervention SCI improves neural behavior via inhibiting increasing